4sc Ag

Kristina Wolf

Stefano Pegoraro

Johann Leban

Harald Schmitt

Andreas Wuzik

Andrea Aschenbrenner

Daniel Vitt

Stefan Tasler

Wael Saeb

Bernd Kramer

Rolf Krauss

Johan Leban

Gabriel Garcia

Matthias Dormeyer

Jürgen Kraus

Andreas Wuzík

Peter Ney

Katharina Aulinger Fuchs

This invention relates to novel aryloxypropanolamines. The invention also relates to the pharmaceutically acceptable salts and solvates containing said compounds, methods for the preparation thereof and to respective synthetic intermediates. Said compounds have agonistic activity at &#x3b2;3 adrenergic receptors and are useful for treatment of ailments influenced by activation of &#x3b2;3 adrenergic receptors.

Aryloxypropanolamines, methods of preparation therof and use of aryloxypropanolamines as medicaments

The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, (I) wherein Ris independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl or substituted arylalkyl; Ris independently &#x2014;NRR, (II) or (III) Ris independently alkyl, cycloalkyl, alkoxy, alkylamine, &#x2014;OH, &#x2014;SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl, Ris independently alkyl, cycloalkyl, alkoxy, alkylamine, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; Ris independently H, COR, COR, SOR, SOR, SOR, alkyl, cycloalkyl, alkoxy, &#x2014;NH, alkylamine, &#x2014;NRCOR, halogen, &#x2014;OH, &#x2014;SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; Ris independently H, alkyl, cycloalkyl, &#x2014;NH, alkylamine, aryl or heteroaryl; Ris independently H, alkyl, cycloalkyl, alkoxy, &#x2014;OH, &#x2014;SH, alkylthio, hydroxyalkyl, aryl, or heteroaryl; p is 0, or 1; q is 0, or 1; X is CO, or SO. 

Heterocyclic NF-&#x3ba;B inhibitors

The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein 

The present invention relates to compounds of the general formula (III) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof, 

Heterocyclic NF-kB inhibitors

The invention relates to new diphenylurea having the formula (I)or a salt thereof, where

Compounds for the treatment of protozoal diseases

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Kottgeisering, Germany

Kristina Wolf