Cardiovascular Systems, Inc.

Kristina Tibesar Jensen

Cassandra Ann Piippo Svendsen

Victor Leo Schoenle

Jeffrey Allen McBroom

Jody Lee Rivers

Ryan D Welty

David James Gennrich

Mark B Oreschnick

Alyson M Borrell

The invention provides systems and methods for mixing of therapeutic agents before and/or during the localized application of the therapeutic agents. Most preferably, the present invention provides systems and methods for mixing of therapeutic agents before and/or during administration of the agents within a biological lumen. Various embodiments of the present invention comprise systems and methods for inducing a mixing state in the therapeutic agents, thereby inducing and/or maintaining homogeneity of the agents before and/or during localized delivery.

Systems and methods for mixing therapeutic agents before and/or during administration

The invention provides a system, device and method for localized application of therapeutic substances within a biological conduit. In various embodiments, a dissolvable bag or bolus of at least one therapeutic agent is introduced and pressed and/or sealed against the wall of conduit. In other embodiments, dissolvable barbs formed from at least one therapeutic agent are ejected from a catheter by fluid pressure, embedding in the wall of conduit.

Therapeutic agent delivery system, device and method for localized application of therapeutic substances to a biological conduit

The invention relates generally to devices and methods for local delivery of therapeutic agents to the wall of a bodily lumen with minimal shearing damage to the therapeutic agents, more specifically to the wall of a blood vessel following atherectomy. A preferred delivery mechanism comprises a balloon, or double balloon, though any distal catheter design may be used to reduce shear stress and to conserve and/or isolate the therapeutic substance.

Devices and methods for low shearing local delivery of therapeutic agents to the wall of a bodily lumen

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Chaska, MN, United States of America

Kristina Tibesar Jensen