Becton Dickinson and Company Limited

Rohm and Haas Company

Kristin Weidemaier

Dwight Livingston

Adam C Curry

J Bruce Pitner

Douglas Byron Sherman

John D DeNuzzio

Steven Keith

Andrea Liebmann-Vinson

Ross Jacobson

Alexander George Lastovich

Robert E Pearson

James L Schram

Melody M H Kuroda

Christian Sandmann

Helen V Hsieh

Qihua Xu

Eric Fallows

Javier Alarcon

Terry J Amiss

Mark A Talmer

Robert L Campbell

Thomas D Haubert

Jack H Kessler

Ammon David Lentz

Michael A Brasch

James A Prescott

Richard L Moore

Michael L Marshall

Gregory S Kramer

Michael Justin Lizzi

Scott Nicholas Danhof

M Scott Ulrich

Artis R Lockhart

Joshua Herr

Michael William Linsen

Randy J Somerville

Kevin G Dolan

David S Sebba

Ernie Ritchey

Patrick Downie

Rajendra R Bhat

Sivaramakrishnan Balasubramanian

Christopher Basciano

Donald E Gorelick

Jon E Salomon

Christopher C Herdman

W William Stewart

Erin Gooch Carruthers

Miroslaw Bartkowiak

Mark Richard Schure

Spencer Lovette

W Shannon Dillmore

Wendy Dale Woodley

Cristian Clavijo

Javier Alarcón

Jeffrey S Ojala

William Shannon Dillmore

Terry J Amis

Ross Wayne Jacobson

Christopher Herdman

Lori Pederson Allphin

Robert A Fulcher

Melody MH Kuroda

Eric A Fallows

Meghan Wolfgang

Owen Lewis Joyce

Henry Li-Wei Fu

Caitlin Marie Austin

Michael L Kiplinger

Sean Connell

Richard Abbot

Alexander Adam Papp

Sean Patrick Dowling

Ross W Jacobson

Adam Craig Curry

William Kevin Carpenter

Shirley Ng

A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.

Biological fluid separation device

Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

Assays using surface-enhanced raman spectroscopy (SERS)-active particles

Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.

Fiber optic device for sensing analytes

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.

Fiber optic device for sensing analytes and method of making same

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is described. An optical conduit, preferably an optical fiber, has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and may include at least one binding protein adapted to bind with at least one target analyte. The sensing element further may also include at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.

An automated fluid formulating system for use in small scale laboratory operations. The system utilizes a computer to provide precise control over the measurement of ingredients and the entire formulating process. The novel feature of this invention is that it can provide precise control over the formulating of high viscosity, high solid fluids, such as emulsions and gels. Further, a pre-programmed cleaning cycle can be input into the computer to automatically clean the mixing elements so that the mixing elements do not contaminate subsequent formulations with materials from the prior formulation.

Automated system and process for the preparation of a high viscosity fluid formulation

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Raleigh, NC, United States of America

Kristin Weidemaier