Takeda Pharmaceutical Company Limited

Kristin Schleicher

Huikai Sun

Holger Monenschein

Jason W Brown

Holly Reichard

Maria Hopkins

Shota Kikuchi

Todd Macklin

Stephen A Hitchcock

Zacharia S Cheruvallath

Mingnam Tang

Jason Green

Ben Johnson

Steve Hitchcock

Hukai Sun

Disclosed are compounds of Formula (1), and pharmaceutically acceptable salts thereof, wherein n, R, R, R, R, R, R, R, R, R, R, X, Xand Xare defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.

N-(heterocyclyl and heterocyclylalkyl)-3-benzylpyridin-2-amine derivatives as SSTR4 agonists

Disclosed are compounds of Formula 1, stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R, R, R, R, R, R, R, X, X, X, X, X, and Xare defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.

Piperidinyl-3-(aryloxy)propanamides and propanoates

The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

Substituted pyrido[3,4-b]pyrazines as GPR6 modulators

Disclosed is a compound of Formula 1, and a pharmaceutically acceptable salt thereof. This disclosure also relates to materials and methods for preparing the compound of Formula 1, to pharmaceutical compositions which contain it, and to its use for treating diseases, disorders, and conditions associated with GPR6.

Tetrahydropyridopyrazine modulators of GPR6

This present invention provides compounds of formula II: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

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San Diego, CA, United States of America

Kristin Schleicher