Isis Pharmaceuticals, Inc.

Ibis Biosciences, Inc.

Kristin Sannes Lowery

Steven A Hofstadler

Richard Holmes Griffey

David J Ecker

Jared James Drader

Susan M Freier

C Frank Bennett

Eric E Swayze

Stanley T Crooke

Rangarajan Sampath

Brenda F Baker

Thomas A Hall

Venkatraman Mohan

Christian Massire

The present invention provides methods for the identification ligand compounds that bind to target molecules such as proteins or structured RNA with as little as millimolar (mM) affinity using mass spectrometry. The methods may be used to determine the mode of binding interaction between two or more of these ligand compounds to the target as well as their relative affinities. Also provided are methods for designing compounds having greater affinity to a target molecule by identifying two or more ligands using mass spectrometry methods of the invention and linking the ligands together to form a novel compound.

Optimization of ligand affinity for RNA targets using mass spectrometry

There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products.

Methods for rapid identification and quantitation of nucleic acid variants

The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associated diseases.

Compositions and methods for the treatment of severe acute respiratory syndrome (SARS)

Growing community of inventors

Vista, CA, United States of America

Kristin Sannes Lowery