Enzyvant Therapeutics Gmbh

Duke University

Kristin Marks

Alex Tracy

Joanne Kurtzberg

Laura P Hale

Gregory D Sempowski

Mary Louise Markert

Karin Pihel

Thomas Stephen Villani

Andrew N MacIntyre

Lynn Cheatham

Michael Thomas Johnson

Methods and compositions for promoting donor-specific tolerance and immunocompetence to a recipient of a solid organ transplant, by implanting an allogeneic solid organ in a recipient in need of a solid organ transplant and further comprising surgical implantation of a tissue-engineered allogeneic cultured postnatal thymus tissue product in the recipient of a solid organ from a donor. Methods of producing an allogeneic cultured postnatal thymus tissue-derived product suitable for implantation into a human; methods of culturing allogeneic cultured postnatal thymus tissue-derived product suitable for implantation into a human and methods of using allogeneic cultured postnatal thymus tissue-derived product by implantation in a human subject.

Methods of determining the suitability of cultured thymus tissue for implantation into humans and associated methods of use

Systems and methods for performing quantitative histopathology analysis for determining tissue potency are disclosed. According to some embodiments, a method training a tissue classifier is provided. According to the method, training the tissue classifier includes generating feature fingerprints of detected nuclei within slide images in a control library and clustering the slide images based on their corresponding feature fingerprints. According to some embodiments, a method for utilizing the trained tissue classifier is provided. According to the method, the trained tissue classifier determines whether tissue in an unknown slide image corresponds to slide images clustered during the training of the tissue classifier.

Tissue potency determination through quantitative histomorphology analysis

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Durham, NC, United States of America

Kristin Marks