Pfizer Corporation

Kristin M Lundy

Hengmiao Cheng

Subas Man Sakya

Martha L Minich

Jin Li

Robert L Dow

Peter Bertinato

Kiyoshi Kawamura

Kazuo Ando

Martin R Jefson

Brian S Bronk

Chikara Uchida

Tomoki Kato

Nigel A Evans

Anthony P Ricketts

Chi Bao Vu

Burton Humphrey Jaynes

Jean-Pierre Pelletier

Carolyn R Kilroy

Methods for the treatment of age-related behavioral disorders in companion animals are disclosed. These comprise administering to a companion animal in need of such treatment a therapeutically effective amount of an acetylcholinesterase inhibitor. A preferred acetylcholinesterase inhibitor is a compound of Formula 1: Pharmaceutical compositions and dosage forms comprising a compound of Formula 1 are also disclosed.

Methods for treating age-related behavioral disorders in companion animals

Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents

Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents

Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives

This invention relates to compounds of formulas 1 and 2 ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein X, X.sup.1, R.sup.1, R.sup.2, R.sup.7, R.sup.17 and R.sup.19 are as defined herein. The compounds of formulas 1 and 2 may be useful in the treatment of bacterial, parasitic and protozoal infections, as well as disorders related to bacterial, parasitic and protozoal infections, in mammals, fish and birds. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and 2 and to methods of treating bacterial, parasitic and protozoal infections by administering the compounds of formula 1 and 2.

3,6-ketal and enol ether macrolide antibiotics

The present invention relates to certain compounds of the formula (I) the racemic-enantiomeric mixtures and optical isomers of said compounds, prodrugs thereof and the pharmaceutically acceptable salts, depicted below, which are .beta.-adrenergic receptor agonists and accordingly have utility as, inter alia, hypoglycemic and antiobesity agents. The invention also relates to methods of use for the compounds and to compositions containing them. The compounds of the present invention also possess utility for increasing lean meat deposition and/or improving the lean meat to fat ratio in animals, e.g., ungulate animals, companion animals, especially dogs, and poultry. The compounds of formula (I) have the following structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification.

.beta.-adrenergic agonists

Derivatives of 16-membered ring 3-deoxy macrolide antibiotic derivatives of rosaramicin, repromicin, 5-mycaminosyltylonolide, desmycosin, lactenocin, O-demethyllactenocin, cirramycin A.sub.1, and 23-deoxymycaminosyltylonolide, which are useful against bacterial and mycoplasmic pathogens in animals.

Antibiotic macrolides

Amide derivatives of 16-membered ring antibiotic macrolides

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Groton, CT, United States of America

Kristin M Lundy