Kancera Ab

Proximagen Limited

Biovitrum Ab (publ)

Neuroscios Gmbh

Kristin Hammer

Erik Ringberg

Bengt L Lindqvist

Rune Ringom

Peter Brandt

Mattias Jönsson

Lars Krüger

Björn M Nilsson

Gary Johansson

Jan Vågberg

Elisabeth Olsson

Katarina Beierlein

Peter Åsberg

Johan Olsson

Katarina Färnegårdh

Johan Angbrant

Martin Henriksson

Sofia Henriksson

Berts Wei

Johan Schultz

Bengt Lindqvist

A compound of formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of a histone deacetylase, and as such is useful in therapy, e.g. in the treatment of autoimmune disorders, mental disorders, neurodegenerative disorders, and hyperproliferative disorders.

Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity

A compound of formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the compound. The compound is useful in therapy, for the treatment of disorders mediated by HDAC6, such as autoimmune disorders, neurodegenerative disorders and hyperproliferative disorders, such as cancer. 

Benzimidazole derivates useful as inhibitors of mammalian histone deacetylase activity

The present invention relates to novel chemical compounds formula (I) (C)&#x2014;B-(A)-B&#x2014;(C)(I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five- and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group (&#x2014;CO&#x2014;), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R. The compounds are useful in therapy, especially therapy of a mammal suffering from a disease involving misfolded or aggregated forms of proteins.

Substituted aromatic oligomers

The present invention relates to compounds of the formula (I) wherein A, X and Rto Rare as described herein; to pharmaceutical compositions comprising the said compounds; to processes for their preparation; and to the use of the compounds as medicaments against 5-HTreceptor-related disorders.

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The present invention relates to novel compounds of formula (I): 

4-substituted indole and indoline compounds

Growing community of inventors

Sollentuna, Sweden

Kristin Hammer