Archemix Corporation

Kristin A Marshall

Martin Stanton

Markus Kurz

Charles Wilson

David Epstein

Thomas Greene McCauley

Jeffrey C Kurz

Dilara Grate

Nobuko Hamaguchi

Tony Keefe

Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.

Nucleic acid sensor molecules and methods of using same

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Arlington, MA, United States of America

Kristin A Marshall