Sri International

University of California

Kristien Mortelmans

Ling Jong

Faming Jiang

Gaoquan Li

Michael E Selsted

Michael Hugh Quinn

Daniel Tus&eacute;

Larry L Chapoy

Leslie A Hokama

Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2'-diindolylmethane, 2&#x2032;,3-diindolylmethane, and 3,3&#x2032;-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

Analogs of indole-3-carbinol and their use as agents against infection

This invention provides a novel anti-microbial system suitable for formulation in a wide variety of ophthalmic solutions. In particular the composition comprises an antimicrobial peptide that is an indolicidin and a buffer compatible with application to a mammalian eye, wherein the buffer is a Good's buffer or the buffer has a halide ion concentration less than 0.85 wt %. The compositions are useful for storing, cleaning, or disinfecting a contact lens. In particular the compositions are self-preserving upon lengthy storage, effective in cleaning and sterilizing contact lenses upon exposure of the lens to the composition, do not require the need for physical or thermal treatment of the lens and enable the immediate application of the lens to the eye without the need for neutralization, deactivation or washing.

Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial

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Los Altos Hills, CA, United States of America

Kristien Mortelmans