Arexis Ab

Immunologia Y Genetica Aplicada, S.a.

Nordic Vaccine Technology A/s

Inmunologia Y Genetica, S.a.

Kristian Dalsgaard

Jose Ignacio Casal Alvarez

Carmen Vela Olmo

Robert Hans Meloen

Elena Cortes Valdes

Ana I Ranz Casares

Bjorn Lowenadler

Peter Kaastrup

Joannes Pieter Langeveld

Nils Lycke

Nikolai Søren Kirkby

Allan Mc Mowat

The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and/or a targeting ligand, and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.

Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides

The invention relates to an immunogenic complex comprising at a least one glycoside and at least one lipid, integrated into an iscom complex or matrix, and at least one antigen which antigen is integrated into the iscom complex or coupled on to or mixed with the iscom complex or iscom matrix complex, characterised in that it also comprises at least one enzyme. It also relates to such a complex further comprising at least one peptide which specifically binds to a receptor expressed on a cell capable of antigen presentation, which cell expresses MHC Class I or Class II and to compositions comprising the complexes.

Immunogenic complex

Synthetic peptides and vaccines against parvovirus

Recombinant subunit vaccine against porcine parvovirus

Growing community of inventors

Kalvehave, Denmark

Kristian Dalsgaard