Camurus Ab

Akzo Nobel Surface Chemistry Ab

Camarus Ab

Goddard, Christopher Robert

Krister Thuresson

Fredrik Tiberg

Fredrik Joabsson

Markus Johnsson

Ian Harwigsson

Margareta Linden

Markus Johansson

Catalin Nistor

The present invention relates to formulation precursors (pre-formulations) for the in situ generation of compositions for the controlled release of the salts of peptide active agents, including somatostatin analogues. The invention also relates to pre-formulations of amphiphilic components and at least one salt of a peptide active agent (e.g., somatostatin analogue) for parenteral application.

Peptide slow-release formulations

The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of:

Topical bioadhesive formulations

The present invention provides a formulation comprising:

Lipid formulations comprising a thiolated antioxidant

The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

Lipid depot formulations

Liquid depot formulations

The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of:

Opioid depot formulations

An aqueous composition is described, which is characterised in that it comprises comprises a water-soluble electrolyte complex containing a combination of a water-soluble, anionic polyelectrolyte with hydrophobic groups having 6-30 carbon atoms, and a water-soluble cationic polyelectrolyte with hydrophobic groups having 6-30 carbon atoms. The polyelectrolyte composition can be used as thickening agent in water-based systems, such as paints, coating slips, cosmetics or cleaning compositions, and as water-binding agent in sanitary products, e.g. nappies, sanitary towels and the like.

Growing community of inventors

Lund, Sweden

Krister Thuresson