Anthrogenesis Corporation

Celularity Inc.

Antrhogenesis Corporation

Clarity Acquisition II LLC

Kristen S Labazzo

James W Edinger

Jia-Lun Wang

Robert J Hariri

Sascha Dawn Abramson

Qian Ye

Marian Pereira

Stewart Abbot

Eric Law

Neerav Dilip Padliya

Vladimir Jankovic

Jennifer Paredes

Mohammad A Heidaran

Herbert Faleck

Aleksandar Francki

Aleksandr Kaplunovsky

Shmuel Yaccoby

Marian Guelakis

Aleksander Francki

Jia-Iun Wang

Marian Periera

Provided herein are methods and compositions for the production of hepatocytes from placenta stem cells. Further provided herein is the use of such hepatocytes in the treatment of, and intervention in, for example, trauma, inflammation, and degenerative disorders of the liver. Also provided herein are compositions and methods relating to combinations of nanofibrous scaffolds and adherent placental stem cells and methods of using the same in cartilage repair. Finally, provided herein are compositions and methods relating to nonadherent, CD34CD45stem cells from placenta.

CD34,CD45placental stem cell-enriched cell populations

Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.

Methods and compositions for treatment of bone defects with placental cell populations

Provided herein are methods of treating individuals having diseases or disorders of the circulatory system, using placental cells, e.g., the placental stem cells and placental multipotent cells (PDACs) described herein, and populations of such placental cells. The invention also provides methods of angiogenesis using such cells or populations of cells comprising such cells.

Angiogenesis using placental stem cells

Provided herein are novel angiogenic cells from amnion, referred to as amnion derived adherent cells, and populations of, and compositions comprising, such cells. Further provided herein are methods of obtaining such cells and methods of using the cells in the treatment of individuals.

Amnion derived adherent cells

Provided herein are osteogenic placental adherent cells (OPACs), methods of using OPACs and OPAC populations, and methods of culturing, proliferating, expanding, or differentiating the OPACs. Further provided herein are methods of using the OPACs to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are methods for treating bone defects with OPACs and compositions comprising OPACs. Also provided herein are methods of using OPACs in the treatment and management of multiple myeloma, e.g., reducing the progression of, halting the progression of, or improving, one or more symptoms of multiple myeloma in an individual having multiple myeloma, comprising administering a plurality of OPACs to the individual.

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Springfield, NJ, United States of America

Kristen S Labazzo