Massachusetts Institute of Technology

Kristala Lanett Jones Prather

Collin Hunter Martin

Tae Seok Moon

Gregory N Stephanopoulos

Parayil K Ajikumar

Michael T Timko

Aditya Kunjapur

Himanshu Hemant Dhamankar

Kyle C Peet

Micah James Sheppard

Adam J E Freedman

Kevin Solomon

Sang-Hwal Yoon

Jason Thomas Boock

Effendi Leonard

Janelle Renee Thompson

Kelly Thayer

Provided herein are methods of producing a bioproduct by culturing a cell in a multiphase reactor that comprises supercritical CO, near critical CO, or liquid CO.

Microbial system for biosynthesis of natural and engineered products coupled to in situ extraction in supercritical CO

The invention relates to recombinant cells and their use in in the production of branched medium-chain alcohols such as 4-methyl-1-pentanol.

Microbial production of branched medium chain alcohols, such as 4-methylpentanol

The invention relates to the production of glucuronic and glucaric acid in cells through recombinant expression of myo-inositol 1-phosphate synthase, myo-inositol oxygenase and uronate dehydrogenase. Cloning and characterization of the gene encoding uronate dehydrogenase is also disclosed.

Cellular production of glucaric acid through recombinant expression of uronate dehydrogenase and myo-inositol oxygenase

Aspects of the invention relate to the design and construction of Metabolite Valves, such as Glucose Valves, that can be used to divert metabolites from endogenous pathways toward alternative pathways in a cell.

Glucose valve and other metabolite valves

The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.

Microbial production of 3,4-dihydroxybutyrate (3,4-DHBA), 2,3-dihydroxybutyrate (2,3-DHBA) and 3-hydroxybutyrolactone (3-HBL)

The invention relates to recombinant cells and their use in the production of 3-hydroxyacids such as 3,4-dihydroxybutyrate and 3-hydroxybutyrolactone.

Microbial production of 3-hydroxyacids from glucose and glycolate

The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.

Growing community of inventors

Milton, MA, United States of America

Kristala Lanett Jones Prather