Oklahoma State University

Louisiana State University and Agricultural & Mechanical College

University of Kansas-ku Medical Center Research Institute

Canopy Growth Corporation

Krishna Kumar Gnanasekaran

Richard A Bunce

Kenneth D Berlin

Baskar Nammalwar

Jeffrey Alan Omeara

Siawash Ahmar

Donghua Howard Zhou

Mario Rivera

Huili Yao

Kate Eshelman

Scott Lovell

Field M Watts, Jr

Ji Sung Park

Anabel Soldano

Achala N D Punchi Hewage

The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I:

Use of small molecule inhibitors of the BfrB:Bfd interaction in biofilms

The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin.

Small molecule inhibitors of the BfrB:Bfd interaction

The synthesis of a range of pentylbezene-1,3-diol compounds of formula I is disclosed. These compounds bind to cannabinoid 1 and 2 receptors (CB1 and CB2), and are thus presumed to be useful in modulating the activity of such receptors. Accordingly, the use of such synthetic cannabinoids in the treatment of various disorders mediated by CB1 and CB2 is contemplated.

Cannabigerol derivatives and use thereof as cannabinoid receptor modulators

This disclosure relates to cannabinoid derivatives having the structure of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in treating or preventing a diseases associated with a cannabinoid receptor in subject in need thereof, wherein the cannabinoid receptor is one or more of CB1, CB2, 5HT1A, 5HT2A, GPR18, GPR55, GPR119, TRPV1, TRPV2, PPARγ or a μ-opioid receptor.

Cannabinoid derivatives

Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.

Chromane-substituted, tetrahydroquinoline-substituted and thiochromane-substituted heteroarotinoids as anti-cancer agents

Chroman-substituted, tetrahydroquinoline-substituted and thiochroman-substituted heteroarotinoids as anti-cancer agents

Growing community of inventors

Mississauga, Canada

Krishna Kumar Gnanasekaran