The Florida State University Research Foundation, Inc

Krishna Damera

Binghe Wang

Chaofeng Dai

Xingyue Ji

Didier Merlin

Yueqin Zheng

Alexander Draganov

Emilie Viennois

Danzhu Wang

Weixuan Chen

Phang-Cheng Tai

Jinshan Jin

Yinghsin Hsieh

Ying-Ju Ritter

Jianmei Cui

Arpana S Chaudhary

Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37&#xb0; C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.

Carbon monoxide-releasing molecules for therapeutic applications and methods for the preparation and use thereof

Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37 C and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.

Carbon monoxide-releasing molecules for therapeutic applications and methods of making and using thereof

Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial infections, such as bacterial infections.

SecA inhibitors and methods of making and using thereof

Growing community of inventors

Smyrna, GA, United States of America

Krishna Damera