Sutro Biopharma, Inc.

Krishna Bajjuri

Ryan Stafford

Gang Yin

Alice Yam

Xiaofan Li

Cristina Abrahams

Andreas Maderna

Qun Yin

Toni Beth Kline

Daniel Calarese

Abigail Yu

Jeffrey Hanson

Miao Wen

Helena Kiefel

Kristin Bedard

Amandeep Gakhal

Venita De Almeida

Adam Antoni Galan

Willy Solis

The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.

Anti-ROR1 antibody conjugates, compositions comprising anti ROR1 antibody conjugates, and methods of making and using anti-ROR1 antibody conjugates preliminary class

Anti-ROR1 antibody conjugates, compositions comprising anti ROR1 antibody conjugates, and methods of making and using anti-ROR1 antibody conjugates

Provided herein are hemiasterlin derivatives, conjugates thereof, compositions comprising the derivatives or conjugates thereof, methods of producing the derivatives and conjugates thereof, and methods of using the derivatives, conjugates, and compositions for the treatment of cell proliferation. The derivatives, conjugates, and compositions are useful in methods of treatment and prevention of cell proliferation and cancer, methods of detection of cell proliferation and cancer, and methods of diagnosis of cell proliferation and cancer. In an embodiment, the hemiasterlin derivatives are according to Formula 1000: or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein Ar, L, W, W, W, SG, and R are as described herein.

Hemiasterlin derivatives for conjugation and therapy

Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases.

Immunomodulator antibody drug conjugates and uses thereof

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Fremont, CA, United States of America

Krishna Bajjuri