Merial Limited

Bracco International Bv

Krishan Kumar

Mark Soll

Michael F Tweedle

Natalya Shub

Monica Tejwani-Motwani

Peter Hanson

C Allen Chang

Robert P Waranis

Mark D Soll

The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.

Long acting injectable formulations

A novel dual functioning excipient for metal chelate contrast agents is disclosed. The present excipient,X[X'(L&#x2032;)],which is the calcium or zinc salt of the calcium or zinc complex of an organic ligand, enhances safety in that it is able to scavenge both free metal ions and free organic ligand.

Dual functioning excipient for metal chelate contrast agents

This invention provides for inter alia, topical anthelmintic formulations which comprise a pharmaceutically active combination consisting of at least one macrocyclic compound and at least one compound selected from the group consisting of praziquantel, morantel and pyrantel, which are dissolved in a non-aqueous solvent or solvent mixture and optionally a thickening agent.

Topical anthelmintic veterinary formulations

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Manalapan, NJ, United States of America

Krishan Kumar