Kyowa Hakko Kogyo Co., Ltd.

Kozue Muramatsu

Takeshi Takahashi

Chikara Murakata

Shiro Akinaga

Nobuyoshi Amishiro

Tsutomu Agatsuma

Yoji Ino

Mayumi Miyata

Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I):{wherein Rand Rare the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a cyano group, an amino group, COR(wherein Rrepresents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.

Estra-1,3,5(10)-triene derivatives

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Sunto-gun, Japan

Kozue Muramatsu