Daikin Industries, Ltd.

Otsuka Pharmaceutical Factory, Inc.

Daikin America, Inc.

Kozue Komazawa

Yuuki Kuwajima

Tatsuya Higuchi

Takeshi Inaba

Junpei Terada

Shoji Fukuoka

Mayuko Taeda

Yosuke Nishimura

Masuhiro Nishimura

Takayuki Dempo

Kyle Brundin

Steve Mariconti

Yoshiko Mohara

Adding silica particles having specified collective characteristics to a fluororubber formulation enhances direct adhesion between the fluororubber formulation and a copolymer upon curing. Specifically, as measured before being mixed into the fluororubber formulation, the silica particles have an average value of the product '(particle size)&#xd7;(circularity)' that is 17.5 nm or higher and 500 &#x3bc;m or lower. The silica particles may also have an average particle size of between 25.0 nm inclusive and 500 &#x3bc;m inclusive, and an average circularity of 0.80 or higher. Alternatively, as measured after being incorporated into the fluororubber formulation and then cured, the silica particles have an apparent average value of the product '(particle size)&#xd7;(circularity)' that is 32.0 nm or higher and 500 &#x3bc;m or lower. The silica particles may also have an apparent average particle size of between 40.0 nm inclusive and 500 &#x3bc;m inclusive as measured after being incorporated into the fluororubber formulation and then cured.

Laminate

When mammal cells are administered by using a container whose surface in contact with the mammal cells is formed of a fluororesin material at least partially having a &#x2014;CFterminal group or a container whose surface in contact with the mammal cells is formed of a fluororesin material having a total number of non-fluorinated group terminals and &#x2014;CFH group terminals in the fluororesin of 70 or less per 1&#xd7;10carbon atoms, or mammal cells are stored or cultured in such a container, the cell adhesion on the container inner surface and the cell survival rate reduction can effectively be suppressed. Therefore, by using these containers, a mammal cell-containing liquid having a high concentration and a high proportion of living cells can be administered, stored or prepared, which contributes to regenerative medicine using the mammal cell-containing liquid (suspension liquid).

Container for cell administration, storage or culturing

The present invention aims to provide a laminate in which a fluororesin layer and a fluororubber layer are firmly bonded even when the fluororesin layer contains a fluororesin having excellently low fuel permeability. The present invention relates to a laminate including a fluororubber layer (A) and a fluororesin layer (B) stacked on the fluororubber layer (A). The fluororubber layer (A) is a layer formed from a fluororubber composition. The fluororubber composition contains a fluororubber (a1) and a basic multifunctional compound having at least two nitrogen atoms in the molecule with a distance between the nitrogen atoms in the molecule of 5.70 &#x212b; or greater. The fluororubber (a1) has an absorption coefficient at 1720 cm, determined after being brought into contact with triethyl amine, of 0.35 or lower. The fluororesin layer (B) is formed from a fluororesin (b1) having a fuel permeability coefficient of 2.0 g&#xb7;mm/m/day or lower.

Laminate, method for manufacturing same, and fluororubber composition

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Osaka, Japan

Kozue Komazawa