Meiji Seika Kaisha, Ltd.

Meiji Seika Kabushiki Kaisha

Kozo Nagaoka

Osamu Makabe

Shigeharu Inouye

Seiji Shibahara

Shunzo Fukatsu

Tsuneo Okonogi

Yuichi Yamamoto

Takayuki Usui

Chuhei Nojiri

Takeo Nomura

Susumu Nishimura

Hiroyuki Hamaguchi

Tsutomu Tsuruoka

Osamu Itoh

Shigeru Hoshiko

Shinichiro Kuriya

Keita Matsunaga

Kiyoyuki Ogata

Nobuko Okada

A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.

2-piperidinecarboxylic acid derivative, oncogene suppressor and agent

Megakaryocyte colony stimulating factor and process for its preparation

A DNA segment of a gene coding for a signal peptide is disclosed the segment is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host by incorporation in the vector DNA. The segment comprises a DNA having a base sequence coding for the peptide having the amino acid sequence from X to Y in the annexed FIG. 1. A vector plasmid to be used for transformation of bacteria belonging to the genus Streptomyces is also disclosed. The plasmid comprises a DNA segment with a base sequence coding for an extra-cellular .alpha.-amylase derived from Streptomyces hygroscopicus SF-1084 strain or a mutant thereof the DNA segment incorporated into a vector plasmid is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host and also having a DNA segment necessary for expression of the gene information of the DNA segment. The present invention may be applied to the production of a desired protein which will be secreted outside the host microorganism. .

Gene coding for signal peptides and utilization thereof

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Yokohama, Japan

Kozo Nagaoka