Sumika Fine Chemicals, Co.,ltd.

Sumitomo Chemical Company, Limited

Kozo Matsui

Nobushige Itaya

Kiyoshi Sugi

Tetsuya Shintaku

Yoshihide Umemoto

Masahide Tanaka

Hiroshi Maeda

Tadashi Katsura

Mitsuhiro Iwasaki

Hiromi Suga

The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII)wherein Ris 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.

Production method of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid C1-6 alkyl ester

Production method of (R)-3 hydroxy-3-(2-phenylethyl) hexanoic acid and intermediate thereof

Production method of hydrazine derivative

Method for producing hydrazine derivative

A series of compounds capable of deriving an intermediate for the production of compound (A) of the following formula,

2-phenylpyridine derivative and production method thereof

A series of compounds capable of deriving an intermediate for the production of a compound (A) of the following formula,

A series of compounds capable of deriving an intermediate for the production of a compound (A) of the following formula, ##STR1## which is an anti-HIV drug, and a production method thereof. To be specific, 4-(pyridin-2-yl)benzaldehyde hydrazone, a production method of this compound, and a production method from this compound to N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethyhidene]hydrazine. In addition, a salt of 2-(4-bromomethylphenyl)pyridine, 2-(4-dibromomethylphenyl)pyridine and a salt thereof, production methods of these compounds, and production methods to derive 4-(pyridin-2-yl)benzaldehyde which is a production intermediate for 4-(pyridin-2-yl)benzaldehyde hydrazone from these compounds.

A method of producing a 2-(p-alkylphenyl)pyridine compound economically, easily and industrially, which comprises adding manganese dioxide and trimethylchlorosilane, or adding manganese chloride to an organic ether solvent, and reacting p-alkylphenylmagnesium halide and 2-halopyridine in the obtained organic ether solvent.

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Osaka, Japan

Kozo Matsui