Eisai Company, Limited

Kozo Akasaka

Youji Yamagishi

Isao Yamatsu

Hironori Ikuta

Kenji Hayashi

Shinya Abe

Takeshi Suzuki

Mitsuaki Miyamoto

Tohru Fujimori

Hiroyuki Yoshimura

Koukichi Harada

Kazuo Okano

Kouji Nakamoto

Akiharu Kajiwara

Satoshi Nagato

Makoto Komatsu

Yoshimasa Machida

Norio Minami

Naoyuki Shimomura

Noritaka Kitazawa

Yoshiharu Yamanishi

Kohshi Ueno

Masahiro Yonaga

Toshikazu Shimizu

Yuki Komatsu

Masataka Ueno

Kunizo Higurashi

Atsushi Nagaoka

Isao Saito

Seiichi Kobayashi

Tetsuya Kawahara

Kouichi Katayama

Nobuhisa Watanabe

Teiji Kimura

Atsuhiko Kubota

Atsushi Sasaki

Kimio Hamamura

Hiroshi Tanaka

Satoshi Katayama

Takao Saeki

Yasutaka Takase

Hiroshi Shirota

Masanori Mizuno

Youichi Iimura

Masayuki Tanaka

Issei Ohtsuka

Makoto Matsui

Yoshinori Sakuma

Motoji Kogushi

Ichirou Yoshida

Takaki Kagaya

Mariko Komatsu

A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof:

Biphenyl derivatives

A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.

A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. ##STR1## wherein R.sup.1 stands for a lower alkyl group, an amino group which may be substituted, or the like; R.sup.2 stands for a group represented by the formula: ##STR2## (wherein R.sup.16 stands for an alkyl group having 1 to 6 carbon atoms, or the like) or the like; R.sup.3 stands for a group represented by the formula: --O--(CH.sub.2).sub.m --Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R.sup.5 stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: ##STR3## (wherein R.sup.6 stands for a hydrogen atom, a lower alkyl group, or the like), --N.dbd., or the like; and B stands for a group represented by the formula: ##STR4## (wherein R.sup.4 stands for a hydrogen or the like), --N.dbd., or the like.

Trisubstituted benzene derivatives, composition and methods of treatment

An oxazolidone derivative represented by formula (I) which has a monoamine oxidase inhibition effect: ##STR1## {wherein A and B each represents a nitrogen atom, a sulfur atom or an oxygen atom, with the proviso than at least one of A and B must be a nitrogen atom, R.sup.1 represents a group of the formula: ##STR2## (in which n and m each represents 0 or an integer of 1 to 4, and R.sup.3 and R.sup.4 each represents a hydrogen atom, a hydroxyl group, a lower alkyl group, etc. ), a group represented by the formula: ##STR3## (in which p and q each represents 0 or an integer of 1 to 4 and X represents an oxygen atom, sulfur atom, etc.) and a group represented by the formula: ##STR4## R.sup.2 represents a hydrogen atom or a lower alkyl group}.

Oxazolidone derivative

A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime either derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,

Diphenylethylene derivatives, pharmaceutical compositions containing

A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,

Diphenylethylene derivatives pharmaceutical compositions containing same

Benzophenone oxime ether compounds, pharmaceutical compositions and

Diphenylethylene derivative and pharmaceutical use

A benzothiazol compound having the formula is disclosed and is effective to inhibit the production of leukotriene. It is useful against allergy, asthma, affections of the skin, allergic rhinitis and affection of a cardiovascular system. ##STR1## in which R20 is ester or amide and --NR5R6 is amino in variety.

Benzothiazole derivative

Diphenyl-methane compounds useful in the treatment of diseases caused by

3-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-2-pyrrolidone and N-substituted derivatives thereof are described. The substituent includes alkyl, alkoxy, alkynyl phenyl-alkylene, hydroxy-alkylene and amino-alkylene. They are effective as an anti-inflammatory, analgesic and antithermic agent, and they have a low toxicity.

3-(3,5-di-tert-butyl-4-hydroxy benzylidene)-2-pyrrolidone and

Optically active alpha-tocopherol is synthesized by a multi-step process using phytol as a starting material. The process does not require an optical resolution step.

Synthesis of optically active d-alpha tocopherol

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Ushiku, Japan

Kozo Akasaka