Santen Pharmaceutical Co., Ltd.

Boehringer Ingelheim International Gmbh

Japan Tobacco Inc.

Koushi Fujisawa

Takashi Nagano

Kenji Oki

Nagayoshi Asano

Takahiro Honda

Masakazu Ban

Hiroyuki Aono

Hiromi Okigami

Tatsuji Kurose

Chinami Kikkawa

A compound useful for preventing or treating dry eye and a medicament for preventing and/or treating dry eye comprising the same which does not substantially impact on the intraocular pressure are provided. A method of preventing and/or treating dry eye in a subject in need thereof, comprising administering a therapeutically effective amount of olodaterol or a salt thereof to the subject is also provided.

Medicament for preventing and/or treating dry eye

The present invention relates to Compounds represented by the formula (I) or salts thereof. In the formula (I), the ring A represents a benzene ring, a thiophene ring, or a pyridine ring; Rrepresents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group; the ring B represents a pyridine ring, a pyrimidine ring, or a quinoline ring; the ring C represents a benzene ring; a pyridine ring, a quinoline ring, or an isoquinoline ring; X and Y, the same or different, represent an oxygen atom or a sulfur atom, with the proviso that the case X is a sulfur atom and Y is an oxygen atom be excluded; Rrepresents a hydrogen atom, a halogen atom, an amino group, a cycloalkylamino group, an alkylcarbonylamino group, an alkyloxycarbonylamino group, an alkylaminocarbonyl group, or a non-aromatic heterocyclic group; and Rand R', the same or different, represent a hydrogen atom, a halogen atom, an alkyl group, a halogeno-alkyl group, or a halogeno-alkoxy group. 

Oxadiazole derivatives and thiadiazole derivatives having neovascularization inhibitory activity

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Ikoma, Japan

Koushi Fujisawa