Kyoto University

Asama Chemical Co., Ltd.

Kyowa Medex Co., Ltd.

Maruha Nichiro Holdings, Inc.

Tanabe Seiyaku Company, Limited

Oriental Yeast Co., Ltd.

Hitachi Chemical Diagnostics Systems Co., Ltd.

Kousaku Murata

Wataru Hashimoto

Mizuo Yajima

Shigeyuki Kawai

Yasuki Fukuda

Hiroshi Oda

Keishi Iohara

Noriyuki Ogawa

Takehide Kimura

Fumi Umehara

Keiko Matsutani

Ichiro Chibata

Hirokazu Matsukawa

Masahiko Kisumi

Saburo Komatsubara

Yoshio Ando

Yuhsi Matsuo

Hiroichi Katsuyama

Shoichi Tomisako

Akihito Ochiai

Fuminori Yoneyama

Hiroyuki Takeda

Bunzo Mikami

Yuhsi c/o Oriental Yeast Co Ltd Matsuo

Hirokazu c/o Oriental Yeast Co Ltd Matsukawa

Yoshio c/o Oriental Yeast Co Ltd Ando

Shoichi c/o Oriental Yeast Co Ltd Tomisako

The present invention provides a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample, and then measuring a substance produced or consumed by the oxidation; and a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample using an enzyme, and then measuring a substance produced or consumed by the oxidation. A method for measuring glycated hemoglobin of the present invention is useful for diagnosing lifestyle-related disease such as diabetes mellitus.

Method for measuring glycated hemoglobin

The present invention provides a protein comprising an amino acid sequence in which arginine at position 61 of a protein comprising the amino acid sequence represented by SEQ ID NO: 1 is substituted to an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, proline, cysteine, methionine, asparagine, glutamine, and aspartic acid; and a method for measuring a glycated hemoglobin in a sample, wherein the method comprises reacting a glycated hemoglobin in a sample with a protease to produce a glycated hexapeptide, then reacting the produced glycated hexapeptide with the aforementioned protein, and measuring a substance produced or consumed by the reaction.

Glycated hexapeptide oxidase and use thereof

This invention provides a method for producing ethanol from mannitol using yeast and a yeast strain that produces ethanol from mannitol. The method for producing ethanol from mannitol comprises culturing yeast strains capable of mannitol assimilation and ethanol production from mannitol in a medium containing mannitol.

Ethanol production from mannitol using yeast

An object of the present invention is to provide a method for producing ethanol from polysaccharide alginate contained in a large amounts in brown algae, using the alginate assimilation capacity of thesp. strain A1 and the strong ethanol production capacity of bacteria such as. Specifically, a method for producing ethanol using alginate as a raw material comprises causing genes encoding proteins and enzymes involved insp. strain A1-derived alginate assimilation and genes encoding enzymes involved in ethanol production to co-exist in a single microorganism and then culturing the microorganism in a medium containing alginate.

Ethanol production from ocean biomass

The present invention provides a novel process for preparing nicotinamide adenine dinucleotide phosphate (NADP). The process of the present invention comprises performing phosphorylation using a polyphosphoric acid or a salt thereof and nicotinamide adenine dinucleotide (NAD) as substrates in the presence of a polyphosphate-dependent NADkinase from a, wherein the reaction solution contains 0.1-15% by weight of the polyphosphoric acid or a salt thereof, and 5-150 mM of a divalent metal ion.

Process for preparing nicotinamide adenine dinucleotide phosphate(NADP)

To provide an immunomodulator in which DNA can be administered orally or percutaneously, not through injection, or can be taken daily like a food, or an immunomodulator food or feed. DNA derived from cells of procaryotes such as , lactic acid bacteria, amino acid producing bacteria and is added to food or molded to be able to administer the same orally, percutaneously or permucosally, or formed into food, feed or the like.

Immunomodulator, immunomodulator food and immunomodulator feed

An antimicrobial composition for eucaryotic microorganisms and method of suppressing the growth of eucaryotic microorganisms requires a procaryotic DNA extract. The antimicrobial composition is effective against numerous types of eucaryotic microorganisms and can be safely added to food and cosmetic products.

Antimicrobial agents for eucaryotic microorganisms and methods of growth suppression of eucaryotic microorganisms using these agents

Antimicrobial agents for eucaryotic microorganisms and methods of growth

An improved method for the fermentative production of L-threonine in a high yield, which comprises cultivating a methionine metabolism-antagonist resistant mutant of Serratia marcescens having L-threonine productivity in a broth to form and accumulate L-threonine therein and recovering accumulated L-threonine from the broth.

Fermentation production of L-threonine

Growing community of inventors

Kyoto, Japan

Kousaku Murata