Fujifilm Corporation

Fuji Photo Film Company, Limited

Toyama Chemical Co., Ltd.

Kouki Nakamura

Katsuyuki Watanabe

Takayuki Ito

Kenji Wada

Makoto Takahashi

Hideki Okada

Yuuta Fujino

Satoshi Shimamura

Motomasa Takahashi

Takuya Matsumoto

Takehiro Yamane

Junichi Imoto

Takeshi Murakami

Naoyuki Hanaki

Junji Nishigaki

Kazuhiro Yokoi

Kenjiro Araki

Hiroaki Tsuyama

Hiroyuki Naitou

Osamu Seshimoto

Hiroshi Shinoki

Yoshihide Iwaki

Masayoshi Kojima

Ryoichi Nemori

Yasunori Okada

Kazuya Takeuchi

Masayoshi Yamamoto

Hiroko Inomata

A photopolymerization initiator which is a compound having a structure in which one or more carbonyl groups that link to a carbon atom are further directly bonded to an aromatic ring of an aromatic acyl group that bonds to a phosphorus atom in an acylphosphine oxide structure. A producing method of a photopolymerization initiator produces the photopolymerization initiator. In a polymerizable composition and an ink jet recording method, the photopolymerization initiator is used. Furthermore, an acylphosphine oxide compound has a partial structure represented by Formula 1 or Formula 2.

Photopolymerization initiator and producing method thereof, polymerizable composition, ink jet recording method, and acylphosphine oxide compound

A photopolymerization initiator which is a compound having a structure in which one or more carbonyl groups that link to a carbon atom are further directly bonded to an aromatic ring of an aromatic acyl group that bonds to a phosphorus atom in an acylphosphine oxide structure. A producing method of a photopolymerization initiator produces the photopolymerization initiator. In a polymerizable composition and an ink jet recording method, the photopolymerization initiator is used. Furthermore, an acylphosphine oxide compound has a partial structure represented by Formula 1 or Formula 2. 

A compound represented by a formula [1D] as shown below (wherein R, R, R, R, Rand Rrepresent a hydrogen atom, an optionally substituted Calkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside. 

Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-&#x3b2;-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same

Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-&#x3b2;-D-arabinofuranosyl) cytosine, synthetic intermediate of thionucleoside, and method for producing the same

The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): wherein X represents a halogen atom, a hydroxyl group or a sulfamoyloxy group, and Y represents &#x2014;C(&#x2550;O)R or &#x2014;CN; wherein R represents a hydrogen atom, an alkoxy group an aryloxy group, an alkyl group, an aryl group or an amino group.

Substituted pyrazino[2,3-d]isooxazoles as intermediates for the synthesis of substituted pyrazinecarbonitriles and substituted pyrazinecarboxamides

Pyrazino[2,3-D]isoxazole derivative which is useful as a production intermediate of pyrazine carboxamide derivative

The present invention provides a method for detecting fluorescence by using a solid support to which a probe molecule to be detected is fixed, wherein background is reduced by using a quenching agent. By using present invention, detection sensitivity of a DNA chip can be increased and stable data can be obtained.

Method of reducing background in fluoresence detection

Fluorescent nucleotides useful for labeling nucleic acids which are represented by the formula: X&#x2014;Y&#x2014;Z wherein X represents a residue of natural or non-natural nucleotide and the like and binds to Y at a basic moiety of the residue; Y represents a divalent bridging group or a single bond; Z represents a monovalent group derived from a compound represented by the formula (I) wherein Rto Rrepresent an alkyl group; Vto Vrepresent a hydrogen atom or a substituent; Lto Lrepresent a methine group; W represents an oxygen atom, a sulfur atom, &#x2014;C(R)(R)&#x2014; or &#x2014;N(R)&#x2014; wherein Rto Rrepresents an alkyl group; Q represents a nitrogen atom or &#x2014;C(V)&#x2014; wherein Vrepresents a hydrogen atom or a monovalent substituent; M represents a counter ion; m represents a number required to neutralize the charge of the molecule; s, t and u represent 0 or 1 or the like, and binds to Y at a reactive group existing in Ror R 

Fluorescent nucleotides and labeling methods using the same

A thin membrane for measuring protease activity, which is formed on a support and, which comprises one or more kinds of substances selected from the group consisting of a transferrin derivative and an albumin derivative and is crosslinked and/or substantially water-insoluble. The membrane enables selective measurement of protease activity of a particular class of protease such as matrix metalloproteinase 7.

Thin membrane for measuring protease activity

Compounds for fluorescence labeling

Growing community of inventors

Ashigarakami-gun, Japan

Kouki Nakamura