Kabushiki Kaisha Yakult Honsha

Kouji Miyazaki

Masahiko Ito

Toshiro Sone

Katsuyoshi Chiba

Tadashi Sato

Satoshi Yoshikawa

Takashi Kinoshita

Ritsuo Aiyama

Wakae Yokoi

Masumi Nakao

Mitsuyoshi Kano

Tomoko Hanamizu

Akira Kushiro

Ryoko Iizuka

Norie Masuoka

Takekazu Okumura

Tomohiko Terai

Kimiyuki Kaneko

Kazuaki Yamaji

Fukiko Nishisaka

Shiro Kusuhara

Kaoru Tochiya

Sachiko Matsumoto

Nobuhiro Hanada

Naohito Saito

Susumu Imai

Naomi Kondo

Yoshiaki Nomura

Shunsuke Baba

A butyrate-producing bacterium belonging tois provided. The amount of butyrate produced is at least 1.5 times that ofYIT 10092(DSM 3319) and is measured by thawing a frozen stock solution of the bacterial strain (a 10% (w/v) skim milk-2% sodium glutamate solution with suspended bacterial cells) (cell count: 2.0 to 5.5&#xd7;10cells/mL), inoculating the solution at 1% to 4 mL of a PY liquid medium supplemented with 33 mM sodium acetate and 0.5 (w/v) % glucose (PYGA medium), followed by anaerobic culture at 37&#xb0; C. for 24 hours, then inoculating the culture solution at 1% to a PYGA medium, followed by anaerobic culture at 37&#xb0; C. for 24 hours, then inoculating the culture solution at 1% to a PY medium containing 33 mM sodium acetate and 0.5 (w/v) % L-sorbose, followed by anaerobic culture at 37&#xb0; C. for 24 hours, and then measuring the butyrate concentration.

Butyrate-producing bacterium and use thereof

Provided is a novel lactic acid bacterium strain which is capable of suppressing production of volatile sulfur compounds by oral bacteria, has no cariogenicity and no causative role in infective endocarditis, and is safe in an oral cavity, and provided is an agent for preventing, improving and/or treating oral diseases and discomforts by use of the bacterial strain. An agent for preventing and/or treating an oral disease, containing, as an active ingredient, at least one lactic acid bacterium selected from, andand having all of the following properties (1) to (6):

Prophylactic or therapeutic agent for oral diseases

Disclosed is a skin property-improving agent which exerts excellent effects by oral administration. The skin property-improving agent for oral administration contains, as an active ingredient, a bacterium belonging to the genusand a bacterium belonging to the genus, or fermented milk containing the two bacteria.

Skin properties improving agent for oral administration

A composition for retarding skin aging which contains an edible herb medicine or medicines round in Taiwan, in particular a plant extract or extracts having melanin formation-unhibiting, elastase-inhibiting, hyaluronidase-inhibiting, active oxygen-eliminating and/or radical-capturing type antioxidant activities, and a medicinally acceptable base and/or additives for external dermal application. The composition is useful in promoting skin whitening effects, maintaining the tension and elasticity of the skin, facilitating skin moistening and providing the skin with anti-inflammatory and/or anti-allergic properties.

Compositions for retarding skin aging

External skin preparations containing one or more members selected from among a fermentation product, which is obtained by treating a bean extract with a microorganism, vitamin A and its derivatives. By potentiating skin cells and accelerating the production of hyaluronic acid, these preparations exert effects of preventing and relieving skin roughness, improving keratin, moistening, and preventing and relieving skin tension failure and wrinkles, thereby efficaciously retarding skin aging.

External skin preparations and process for producing the same

Growing community of inventors

Minato-ku, Japan

Kouji Miyazaki