Chugai Seiyaku Kabushiki Kaisha

Kouji Furuno

Minoru Shindo

Sakae Takaku

Nobuhiro Oi

Shigeyuki Kataoka

Takeaki Hirano

Motoharu Shiba

Akira Okazaki

Syuzo Matsubara

Akitoshi Shioya

A pharmaceutical composition for prevention and treatment of gastritis and peptic ulcer of mammals including human beings which contains a bis(benzamido)benzene derivative represented by the formula ##STR1## wherein X and Y are as defined hereinbelow, or an acid addition salt thereof, as an active ingredient, and a method of the use thereof are disclosed.

Pharmaceutical composition and method of the use thereof

Bis(benzamido)-benzene derivatives having various pharmaceutical activities such as activity for preventing and treating peptic ulcer, peripheral vasodilating action, hypotensive activity and analgesic activity and represented by the formula ##STR1## wherein X, Y, Z, R.sub.1, R.sub.2 and R.sub.3 are as defined hereinafter and a process for preparing the same are disclosed.

Bis(benzamido)-benzene derivatives

A pharmaceutical composition for prevention and treatment of gastritis and peptic ulcer of mammals including human beings which contains a bis(benzamido)-benzene derivative represented by the formula ##STR1## wherein X and Y are as defined hereinbelow or an acid addition salt thereof as an active ingredient, and a method of the use thereof are disclosed.

Side effects of an aminoglycoside antibiotic, renal toxicity and 8th nerve toxicity, are reduced by administering a glucosaccharic acid as well as the aminoglycoside antibiotic. An improved method for treating bacterial infection using an aminoglycoside antibiotic and a pharmaceutical composition of an aminoglycoside antibiotic with reduced side effects are disclosed.

Growing community of inventors

Kokubunji, Japan

Kouji Furuno