Morinaga Milk Industry Co., Ltd.

Kouichirou Shin

Koji Yamauchi

Yoshitaka Tamura

Hiroyuki Wakabayashi

Kimiyasu Shiraki

Masahiko Kurokawa

Ayako Horigome

Nobuo Ichihashi

Tetsuya Ando

A process for producing lactoperoxidase, including: a step (1) for bringing one or more milk materials into contact with a cation exchanger having weakly acidic groups as ion exchange groups to thereby effect adsorption treatment; a step (2) for washing the cation exchanger after the adsorption treatment; a step (3) for bringing the cation exchanger after the washing into contact with a leaching solvent to thereby obtain a leaching solution having lactoperoxidase eluted into the leaching solvent; a step (4) for concentrating the leaching solution through an ultrafiltration membrane to thereby effect precipitation in the concentrated leaching solution; and a step (5) for obtaining a lactoperoxidase solution by removing the precipitation from the concentrated leaching solution.

Process for producing lactoperoxidase

An interleukin-6 suppressive agent comprising lactoperoxidase as an active ingredient is used as a pharmaceutical preparation or the like for prevention and/or therapy of a disease caused by production of interleukin-6, such as thrombocytosis, myeloma, Castleman syndrome, rheumatoid arthritis, or influenza-virus infectious disease.

Interleukin-6 suppressive agent

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Zama, Japan

Kouichirou Shin