Kuraray Co., Ltd.

Kouichiro Kawai

Takashi Nishida

Fumio Mori

Iwao Ebashi

Masafumi Okada

Shigeru Tsukagoshi

Shuji Miki

Tazuko Tashiro

A pullulan derivative having one or more active sites resulting from introduction of sulfuric acid, phosphoric acid, a sulfonic acid or a carboxylic acid, wherein one hydrogen atom of the group of the formula ##STR1## occurring at said active sites is partly substituted by a group of the general formula ##STR2## wherein L.sup.1 and L.sup.2 each independently is amine or a unidentate ligand amine or combinedly represent a bidentate ligand amine and Y is an anionic ligand, and/or two hydrogen atoms of the group ##STR3## groups bound to one and the same carbon atom or to two neighboring carbon atoms as occurring at said active sites are, each independently, partly substituted by a group of the general formula ##STR4## wherein L.sup.1 and L.sup.2 are as defined above, and a pharmacologically acceptable salt thereof. The above compound has anticancer activity and is useful as anticancer agents. The present invention is concerned with said compound, a process for producing the same and a pharmaceutical use thereof.

Platinum containing pullulan derivatives and pharmaceutical compositions

Platinum containing pullulan derivatives and compositions containing the

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Okayama, Japan

Kouichiro Kawai