The Green Cross Corporation

Kouichi Yamanouchi

Kirby V Scherer, Jr

Kazumasa Yokoyama

Taizo Ono

Yoshio Tsuda

Ryoichiro Murashima

Kimie Naito

Ryoichi Naito, Deceased

There is provided a novel perfluorochemical represented by the formula, ##STR1## wherein R.sub.F is a perfluoroalkyl group, a perfluoro alkoxyalkyl group or a perfluoroalkyloxy group, X and X' are same as or different from each other and are a fluorine atom or a perfluoroalkyl group, and Y is a perfluoroalkyloxy group or a perfluoro dialkylamino group, the total number of the carbon atoms contained being an integer of 8 to 11 inclusive. The perfluorochemical is prepared by perfluorinating the corresponding partially fluorinated compound which may have unsaturated hydrocarbon moiety, only with molecular fluorine in a stoichiometric excess amount in an inert solvent. The perfluorochemical is used for preparing a stable emulsion as blood substitutes or perfusion media.

Perfluoro branched alkyl ethers and emulsions

Perfluorochemicals and process for preparing the same

The present invention relates to novel perfluoro chemicals (PFC), particularly perfluorocyclic ethers and polyfluorinated compounds containing a few chlorine atoms and to a method for the preparation thereof.

Perfluoro chemicals and polyfluorinated compounds

Novel persistent perfluorinated free radicals are disclosed, which upon thermal decomposition yield free radicals which can be used to polymerize polymerizable monomers containing ethylenic unsaturation.

Persistent perfluoroalkyl free radicals useful as polymerization catalyst

Novel perfluoro chemicals and polyfluorinated compounds and process for

50-95 Parts by weight of a perfluorocarbon compound such as perfluorodecalin, perfluoromethyldecalin, perfluoro alkylcyclohexanes having 3 to 5 carbon atoms in the alkyl, perfluoro alkyltetrahydrofurans having 5 to 7 carbon atoms in the alkyl, perfluoro alkyltetrahydropyrans having 4 to 6 carbon atoms in the alkyl, perfluoroalkanes having 9 to 11 carbon atoms, and 50-5 parts by weight of a perfluoro tert.-amine such as perfluoro tert.-alkylamines having 9-11 carbon atoms, perfluoro N-alkylpiperidines having 4 to 6 carbon atoms in the alkyl, and perfluoro N-alkylmorpholines having 5 to 7 carbon atoms in the alkyl are emulsified in an aqueous medium by the aid of a high-molecular-weight nonionic surfactant have a molecular weight of about 2,000 to 20,000, and phospholipids as emulsifying agent, and fatty acids having 8 to 22 carbon atoms or salts or monoglycerides thereof as emulsifying adjuvant. The resulting oxygen-transferable emulsion having a particle size of 0.05 to 0.25.mu. is very stable for a long period of time, can be mixed with plasma extenders, and retains for long time in the blood stream of animals when it is used as an artificial blood substitute while being excreted very rapidly.

Growing community of inventors

Sakai, Japan

Kouichi Yamanouchi