Panasonic Intellectual Property Management Co., Ltd.

Panasonic Corporation

The University of Tokyo

Mitsubishi Tanabe Pharma Corporation

Kouichi Wada

Takashi Saito

Ayako Tsukitani

Toshihide Mori

Kensuke Yamazoe

Yoshinori Karasawa

Hiroshi Hamano

Akira Takashima

Yoshihiro Shimizu

Naohiro Toda

Hiroki Noguchi

Takashi Kanamori

Takuya Ueda

Yasuhiro Fujino

Sayaka Nishi

Kotomi Oda

Risako Fujita

The polynucleotide construct of (1) or (2) below is used to perform ribosome display, CIS display and/or mRNA display in order to screen a Fab against an antigen of interest: (1) a polynucleotide construct which monocistronically comprises a ribosome-binding sequence, Fab first chain-coding sequence, linker peptide-coding sequence, Fab second chain-coding sequence and scaffold-coding sequence in this order, and further comprises at its 3'-end a structure necessary for maintaining a complex with the Fab encoded by itself; and (2) a polynucleotide construct which comprises a Fab first chain-expressing cistron and a Fab second chain-expressing cistron each containing a ribosome-binding sequence, a Fab first chain-coding sequence or Fab second chain-coding sequence, and a scaffold-coding sequence in this order, the first Fab-expressing cistron further comprising at its 3&#x2032;-end a ribosome stall sequence, said Fab second chain-expressing cistron further comprising at its 3&#x2032;-end a structure necessary for maintaining a complex with the Fab encoded by itself.

Polynucleotide construct capable of displaying fab in a cell-free translation system, and method for manufacturing and screening fab using same

A lighting device is provided with an illumination unit including two or less LED light sources. The illumination unit uses the two or less LED light sources to emit light of a short wavelength band and light of a long wavelength band. An output varying unit functions to vary an output of at least the long wavelength band light. When the output varying unit receives a varying signal, the output varying unit functions to decrease the output of at least the long wavelength band light.

Lighting device

A lighting device includes a first light source having a first S/P ratio, a second light source having a second S/P ratio that is higher than the first S/P ratio, and a controller configured to performing dimming control of light output from the first and second light sources. The controller performs the dimming control separately on the first and second light sources at least under a snow covered condition.

A lighting device includes first and second light emission units. The first light emission unit emits light having a relatively low color temperature and a high feeling of contrast index. The second light emission unit emits light having a relatively high S/P ratio, which is the ratio of scotopic luminance to photopic luminance. The first light emission unit illuminates a region located at a vertical upper side of a region illuminated by the second light emission unit.

Growing community of inventors

Osaka, Japan

Kouichi Wada