D. Western Therapeutics Institute, Inc.

Kouichi Takahashi

Hiroyoshi Hidaka

Yoshihiro Inoue

Kengo Sumi

Ryohei Nakamura

The present invention provides an isoquinoline-6-sulfonamide derivative that is useful as a novel pharmaceutical agent. The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a salt thereof, or a solvate of the derivative or the salt: wherein X and Y each independently represent a direct bond, NH, CH&#x2550;CH, O, or S; Rand Reach independently represent a hydrogen atom, a halogen atom, a cyano group, an alkyl group, or the like; Rand Reach independently represent a hydrogen atom, an alkyl group, or the like, or Rand Rtogether form an alkylene group or an alkenylene group, which may be bridged between two carbon atoms to an arbitrary position; and l, m, and n represent an integer number of 1 to 4. 

Substituted isoquinoline derivative

The present invention provides a novel isoquinoline-6-sulfonamide derivative that is useful as a medicine. The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a salt thereof, or a solvate of the derivative or the salt, wherein Rand Reach independently represent a hydrogen atom, or the like; Rand Reach independently represent a hydrogen atom, an alkyl group, or the like; Rrepresents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted cycloalkyl group, an optionally substituted alkanoyl group, or the like; and A represents a linear or branched alkylene group having 2 to 6 carbon atoms. 

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Nagoya, Japan

Kouichi Takahashi