Eisai Company, Limited

Director-general of the Agency of Industrial Science and Technology

General Director of the Agency of Industrial Science and Technology

Kouichi Suzuki

Isao Yamatsu

Takeshi Suzuki

Shinya Abe

Kouji Yamada

Yuichi Inai

Yoshikazu Suzuki

Osamu Tagaya

Kouichi Abe

Shizumasa Kijima

Yoshimasa Takahara

Koichi Abe

Kenji Nakajima

Akio Sato

Toshihiko Nakamura

A novel compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed together with a number of different processes for the preparation of the compound. The uses of the novel compound as an agent for treating papillomata are also disclosed.

3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid composition

Skin diseases with keratinization and allergic or inflammatory skin diseases are treated by orally or parenterally administering to an adult human patient from 40 mg to 4 g/day of a polyprenyl compound having the formula (I): ##STR1## in which each of n and m is 0, 1, or 2, n+m is 0, 1 or 2, A is ##STR2## and B is ##STR3## [in which R represents the hydroxyl group, a lower alkoxy group, or ##STR4## (wherein each of R.sub.1 and R.sub.2 is the hydrogen atom, a lower alkyl group or an aryl group)]; provided that R is a lower alkoxy or ##STR5## if n is 1, m is 0, a is ##STR6## and B is ##STR7##

Method of treating skin diseases

A novel compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed together with a number of different processes for the preparation of the compound. The uses of the novel compound as an anticancer agent are also disclosed.

3,7,11,15-Tetramethyl-2,4,6,10,14,-hexadecapentaendic acid

An anti-cancer agent which comprises a polyprenvl compound having the formula (I): ##STR1## in which each of n and m is 0, 1 or 2, n+m is 0, 1 or 2, A is ##STR2## and B is ##STR3## in which R represents the hydroxyl group, a lower alkoxy group, or ##STR4## (wherein each of R.sub.1 and R.sub.2 is the hydrogen atom, a lower alkyl group or an aryl group)]; provided that R is a lower alkoxy or ##STR5## if n is 1, m is 0, A is ##STR6## and B is ##STR7##

Method of treating cancerous and precancerous conditions

A conjugated polyprenylcarboxylic acid and its derivative having the formula: ##STR1## in which each of n and m is 0, 1 or 2, n+m is 1 or 2, A is ##STR2## and R is the hydroxyl group, a lower alkoxy group or ##STR3## wherein each of R.sub.1 and R.sub.2 represents the hydrogen atom, a lower alkyl group, or an aryl group; provided that R is ##STR4## if A is ##STR5## n is 1 and m is 0.

Conjugated polyprenylcarboxylic acids and their derivatives

Longer carbon chain polyprenyl ketone derivatives are prepared by cultivag Nocardia strain FERM-P No. 1609 in the presence of shorter carbon chain polyprenyl ketones.

Process for the preparation of polyprenyl ketone derivatives

This invention relates to novel polyprenyl ketone derivatives having the eral formula: ##STR1## in which n is an integer of 1-5, and R represents a hydroxymethyl, formyl or carboxyl group, and a process for the preparation of the same.

Growing community of inventors

Kakamigahara, Japan

Kouichi Suzuki