Kureha Kagaku Kogyo Kabushiki Kaisha

Kouichi Niimura

Chikao Yoshikumi

Takao Ando

Takao Furusho

Shigeaki Muto

Akihiko Kanno

Masahiko Fujii

A penicillin derivative having an antibacterial activity similar to a penicillin antibiotic in a living body without affecting the intestinal bacterial colonies, a process for preparing the derivative and a pharmaceutical composition in a dosage unit form containing the derivative as an active ingredient are disclosed.

Penicillin derivative

A cephalosporin derivative having an antibacterial activity similar to a cephalosporin antibiotic in living bodies without affecting the intestinal bacterial colonies, a method for preparing the derivative and a pharmaceutical composition in a dosage unit form containing the derivative as an active ingredient are disclosed.

Cephalosporin derivative

A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 atoms or an alkali metal and R is --CH.sub.2 COOR', --CH.sub.2 CH.sub.2 SR', ##STR2## or --CH.sub.2 CH.sub.2 COOR' wherein R' is defined above. A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.

Cephalosporin derivative and pharmaceutical composition containing the

A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkali metal. A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.

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Sayama, Japan

Kouichi Niimura