Mitsui Toatsu Chemicals, Incorporated

Kouhei Yazawa

Hiroyuki Yamashita

Kunio Okumura

Kenji Kibayashi

Toshiyuki Shimazaki

Michihiko Miyamoto

Yuki Nakajima

Yoji Aoki

Takanori Yutaka

Isao Yokoyama

Akihito Kanematsu

The invention relates to a substituted amidine derivative which has an excellent platelet aggregation inhibiting action on the basis of fibrinogen antagonism and is particularly excellent in effectiveness on oral administration, and the platelet aggregation inhibitor containing the substituted amidine derivative of the invention as an effective ingredient is effective for prevention and treatment of thrombosis, and restenosis or reocclusion after percutaneous transluminal coronary angioplasty or percutaneous transluminal coronary recanalization.

Amidine derivatives and platelet aggregation inhibitor containing the

The invention relates to a novel compound which is represented by the formula (1) and has an excellent platelet aggregation inhibiting action based on fibrinogen antagonism. The platelet aggregation inhibitor containing the compound of the formula (1) as an effective ingredient are effective for prevention and curing of thrombosis and restenosis or reocclusion after percutaneous transluminal coronary angioplasty or percutaneous transluminal coronary recanalization.

Bicyclic compound and platelet aggregation inhibitor containing the same

Growing community of inventors

Chiba-ken, Japan

Kouhei Yazawa