Shionogi Company Limited

Shionogi & Co., Ltd.

Kouhei Nodu

Yoshikazu Sasaki

Tomokazu Yoshinaga

Yuji Nishiura

Yusuke Tateno

Kengo Masuda

Masaaki Matoyama

Hiroto Akaza

Shinji Suzuki

Toshiyuki Akiyama

Takashi Fukuda

The present invention provides the compound represented by the following formula (I): or the like;y is 0 or 1; Ris hydrogen or the like; Rand Rare taken together with an adjacent carbon atom to form ring B; ring B is a substituted or unsubstituted non-aromatic carbocycle or the like; Ris hydrogen or the like; Ris hydrogen or the like; Ris represented by formula: Lis a single bond or the like; Lis —C(═O)— or the like; La is a single bond or the like; Ris substituted or unsubstituted alkyl or the like; Ris substituted or unsubstituted alkyl or the like; Ris each independently halogen or the like.

Fused ring derivative having MGAT-2 inhibitory activity

The present invention provides the compound represented by the following formula (I): wherein a moiety represented by formula: is or the like. The symbols are defined in the specification. The compounds of the present invention have MGAT2 inhibitory activity, and are useful as a medicine for treatment of MGAT2-associated diseases including obesity, metabolic syndrome, hyperlipidemia, hypertriglyceridemia, hyper-VLDL-triglyceridemia, hyperfattyacidemia, diabetes mellitus, and arteriosclerosis.

The present invention provides the compound represented by the following formula (I):  or the like. The symbols are defined in the specification. The compounds of the present invention have MGAT2 inhibitory activity, and are useful as a medicine for treatment of MGAT2-associated diseases including obesity, metabolic syndrome, hyperlipidemia, hypertriglyceridemia, hyper-VLDL-triglyceridemia, hyperfattyacidemia, diabetes mellitus, and arteriosclerosis.

The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.

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Osaka, Japan

Kouhei Nodu