Shionogi & Company Limited

Kouhei Nodu

Yoshikazu Sasaki

Tomokazu Yoshinaga

Yuji Nishiura

Yusuke Tateno

Kengo Masuda

The present invention provides the compound represented by the following formula (I): or the like;y is 0 or 1; Ris hydrogen or the like; Rand Rare taken together with an adjacent carbon atom to form ring B; ring B is a substituted or unsubstituted non-aromatic carbocycle or the like; Ris hydrogen or the like; Ris hydrogen or the like; Ris represented by formula: Lis a single bond or the like; Lis —C(═O)— or the like; La is a single bond or the like; Ris substituted or unsubstituted alkyl or the like; Ris substituted or unsubstituted alkyl or the like; Ris each independently halogen or the like.

Fused ring derivative having MGAT-2 inhibitory activity

The present invention provides the compound represented by the following formula (I): wherein a moiety represented by formula: is or the like. The symbols are defined in the specification. The compounds of the present invention have MGAT2 inhibitory activity, and are useful as a medicine for treatment of MGAT2-associated diseases including obesity, metabolic syndrome, hyperlipidemia, hypertriglyceridemia, hyper-VLDL-triglyceridemia, hyperfattyacidemia, diabetes mellitus, and arteriosclerosis.

The present invention provides the compound represented by the following formula (I):  or the like. The symbols are defined in the specification. The compounds of the present invention have MGAT2 inhibitory activity, and are useful as a medicine for treatment of MGAT2-associated diseases including obesity, metabolic syndrome, hyperlipidemia, hypertriglyceridemia, hyper-VLDL-triglyceridemia, hyperfattyacidemia, diabetes mellitus, and arteriosclerosis.

The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.

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Osaka, Japan

Kouhei Nodu