Shionogi Company Limited

Kouhei Matsui

Osamu Yoshida

Kenji Morimoto

Yuuki Ogata

Kazuyuki Minagawa

The present invention provides novel glycopeptides antibiotic derivatives comprising a sugar residue (I) represented by the formula: (wherein n is an integer of 1 to 5: Sugs are each independently a monosaccharide, (Sug)is a divalent sugar residue formed by binding of same or different 1 to 5 monosaccharides; Ris optionally substituted lower alkyl, optionally substituted lower alkenyl, or optionally substituted cycloalkyl; and Ris OH or NHAc (Ac is acetyl)) is bound to an aromatic ring of the fourth amino acid residue in the glycopeptide skeleton. These derivatives have antibacterial activity against vancomycin-resistant bacteria.

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Osaka, Japan

Kouhei Matsui