Sankyo Company, Limited

Kouhei Furuya

Masao Kuroda

Yoshio Tsujita

Seigo Iwado

Kiyoshi Hamano

Tsuyoshi Hosoya

Takeshi Oshima

Takao Okazaki

Nobufusa Serizawa

Tatsuji Matsuoka

Hideyuki Haruyama

Kazuhiko Tanzawa

Kunio Nakano

Toshiaki Iwai

Aiya Sato

Michihiro Sugano

Tadashi Hata

Harumitsu Kuwano

Masami Miura

Takeshi Kinoshita

Noriyoshi Uchida

Masaaki Miyamoto

Atsushi Hattori

Takeshi Kagasaki

Mitsuyo Takahashi

Isolated cultures of Pestalotiopsis funerea IFO 5427 and Pestalotiopsis neglecta FERM BP-3501 are provided. The cultures produce a glucoamylase which digests starch.

Isolated cultures of Pestalotiopsis funerea IFO 5427 and Pestalotiopsis

Trans-4-hydroxy-L-proline is produced microbially, especially by the cultivation of a microorganism of the genus Clonostachys, Gliocladium or Nectria.

Isolated cultures of microorganisms of Clonostachys Cylindrospora,

Microbial process for the production of trans-4-hydroxy-L-proline

A series of new compounds, called 'the phomactins' is provided and may be isolated from the culture broth of fungi of the genus Phoma. especially Phomas sp. SANK 11486 (No. FERM BP-2598). These compounds are platelet activating factor antagonists and may be used for the treatment of disorders for which known such agents may also be used.

Platelet activating factor antagonists, named 'the phomactins', their

Derivatives of ML-236B carboxylic acid, its salts and esters and corresponding lactone have a hydroxy group at the 3'-position and optionally also at the 6'-position. These derivatives may be prepared by the enzymatic hydroxylation of a corresponding ML-236B compound employing an enzyme produced by a microorganism of the genus Streptomyces or Amycolata, especially Streptomyces sp. SANK 62285, Streptomyces sp. SANK 62385, Streptomyces sp. SANK 62485, Streptomyces sp. SANK 62585, Amycolata autotrophica SANK 62781. Amycolata autotrophica subsp. canberrica SANK 62882 or Amycolata autotrophica subsp. amethystina SANK 62981. These derivatives have the ability to inhibit cholesterol biosynthesis.

Hydroxy-ML-236B derivatives, their preparation and use

Derivatives of ML-236B carboxylic acid, its salts and esters and corresponding lactone have a hydroxy group at the 3'-position and optionally also at the 6'-position. These derivatives may be prepared by the enzymatic hydroxylation of a corresponding ML-236B compound employing an enzyme produced by a microorganism of the genus Streptomyces or Amycolata, especially Streptomyces sp. SANK 62285, Streptomyces sp. SANK 62385, Streptomyces sp. SANK 62485, Streptomyces sp. SANK 62585, Amycolata autotrophica SANK 62781, Amycolata autotrophica subsp. canberrica SANK 62882 or Amycolata autotrophica subsp. amethystina SANK 62981. These derivatives have the ability to inhibit cholesterol biosynthesis.

Hydroxyl-ML-236B derivatives, their preparation and use

A series of new compounds, called 'the phomactins' is provided and may be isolated from the culture broth of fungi of the genus Phoma, especially Phoma sp. SANK 11486 (No. FERM BP-2598). These compounds are platelet activating factor antagonists and may be used for the treatment of disorders for which known such agents may also be used.

Platelet activating factor antagonists, named 'the phomactins' their

A new compound, which we have named 'Leualacin' has the formula (I): ##STR1## and may be prepared by cultivation of a microorganism of the genus Hapsidospora, especially Hapsidospora irregularis. The compound may be used for the treatment and prophylaxis of cardiovascular diseases and disorders, especially hypertension.

Compound 'Leualacin', its preparation and its use in the treatment of

Monacolin K, which is an antihypercholesteraemic agent of molecular formula C.sub.24 H.sub.36 O.sub.5, is prepared by cultivating one or more of the microorganisms Monascus anka SANK 10171 (IFO 6540), Monascus purpureus SANK 10271 (IFO 4513), Monascus ruber SANK 10671 (FERM 4958), Monascus vitreus SANK 10960 (FERM 4960), Monascus paxii SANK 11172 (IFO 8201), Monascus ruber SANK 13778 (FERM 4959), Monascus ruber SANK 15177 (FERM 4956) or Monascus ruber SANK 18174 (FERM 4957) in a suitable culture medium and then isolating the Monacolin K from the resulting culture broth.

Preparation of Monacolin K

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Tokyo, Japan

Kouhei Furuya