Oji Holdings Corporation

Kotaro Ishikawa

Takuya Kato

Suguru Ishikawa

Toru Koga

Takuro Kashiwamura

Yaping Chao

Hisako Tokuno

Atsushi Furujyo

Jun Sugiura

Motohiro Matsumura

The present invention provides a pentosan polysulfate having a uronic acid content of 0.0% by mass to 6.0% by mass, preferably a pentosan polysulfate having a structure represented by Formula I: wherein each R represents a hydrogen atom, &#x2014;COCHor &#x2014;SOX, and at least one R represents &#x2014;SOX, wherein X represents a hydrogen atom or a monovalent or divalent metal, and n represents an integer of 1 or more and 30 or less; a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable solvate of the pentosan polysulfate or of a pharmaceutically acceptable salt thereof. The present invention further provides a method for producing pentosan polysulfate, the method comprising the steps of depolymerizing a plant-derived raw material to obtain neutral xylooligosaccharide and sulfating the neutral xylooligosaccharide, in this order.

Pentosan polysulfate and method for producing pentosan polysulfate

The present invention provides a method for producing pentosan polysulfate, the method including a first step of obtaining an acidic xylooligosaccharide from a plant-derived raw material, and a second step of obtaining pentosan polysulfate from the acidic xylooligosaccharide. The first step includes a step of depolymerizing the plant-derived raw material. The second step includes a step of sulfating the acidic xylooligosaccharide. The method further includes a deacetylation step of adding a base to achieve a pH of 11 or higher. The deacetylation step is a step performed after the depolymerization step. The production method of the present invention can provide pentosan polysulfate having a low acetyl group content, and also produce pentosan polysulfate with a high yield inexpensively and efficiently.

Production method for pentosan polysulfate

The present invention provides a reduced-cost method for producing an acidic xylooligosaccharide, the method including a depolymerization step of depolymerizing a plant-derived raw material and a deacetylation step of adding a base to a solution of the product of the depolymerization step to achieve a pH of 11 or higher. The present invention further provides an acidic xylooligosaccharide having an acetyl group content of 0 to 5.0 mass %. The acidic xylooligosaccharide of the present invention, which has an acetyl group content of 0 to 5.0 mass %, can be used as a starting material in a production method to thereby obtain pentosan polysulfate with a high yield.

Production method for acidic xylooligosaccharide, and acidic xylooligosaccharide

The present invention provides a novel topical moisturizing preparation containing as an active ingredient at least one selected from pentosan polysulfate; pharmaceutically acceptable salts of pentosan polysulfate; and pharmaceutically acceptable solvates thereof. The topical moisturizing preparation of the present invention, which contains a substance free of animal-derived components as an active ingredient, can be produced as a topical moisturizing preparation free of animal-derived components, as needed.

Moisturizing topical preparation

The present invention provides pentosan polysulfate having a weight average molecular weight of 5000 or less and a content of acetyl groups of 0% to 2.0% by mass, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. The pentosan polysulfate of the present invention, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof exhibits an anti-Xa activity and an anti-Xa/anti-IIa activity ratio, which are suitable for practical use, and is useful as a pharmaceutical composition such as an anticoagulant.

Pentosan polysulfate, pharmaceutical composition, and anticoagulant

A method for the enzymatic saccharification of a lignocellulosic raw material, including adding a pretreated lignocellulosic raw material as a material suitable for an enzymatic saccharification reaction, together with an electrolyte containing a water-soluble salt, to water that contains a celluolose saccharification enzyme; saccharifying the raw material by an enzymatic saccharification reaction, as a suspension of the raw material having an electrical conductivity adjusted to 5-25 mS/cm; separating and recovering a reaction product and an enzyme-containing solution from the enzymatically saccharified treatment suspension; and recycling the recovered enzyme-containing solution as the enzyme for the enzymatic saccharification step.

Method for enzymatic saccharification treatment of lignocellulose-containing biomass, and method for producing ethanol from lignocellulose-containing biomass

Growing community of inventors

Tokyo, Japan

Kotaro Ishikawa