Aska Pharmaceutical Co., Ltd.

Teikoku Hormone Mfg. Co., Ltd.

Kotaro Gotanda

Hideo Kobayashi

Makoto Okada

Youichi Nakano

Atsushi Shinbo

Kenyu Shibata

Kikuo Yasuda

Toshimi Seki

Tsutomu Ishimori

Shuichiro Sato

Nobuyoshi Minami

Katsuhiko Miyasaka

Masafumi Shiraiwa

Takako Sasaki

Tomio Nakao

Kenji Kawade

Akira Asagarasu

Akihiro Izumi

Seijiro Honma

Takeshi Masuda

Kohichi Hasumi

Masako Uno

The invention discloses quinoxaline derivatives or salts thereof having PDE9-inhibiting activity and being useful as treating agent of dysuria and the like, which are represented by the formula (I) in the formula,

Substituted pyrrolo[1,2-a]quinoxalines as PDE9 inhibitors

Substituted imidazo[1,5-A]quinoxalines as phosphodiesterase 9 inhibitors

This invention provides thienopyrimidine derivatives of the formula, 

Thienopyrimidine derivatives

Substituted imidazo[1,5-A] quinoxalines as a PDE9 inhibitor

A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.

Pyridazinone derivatives

Carbostyril substituted pyridazinones

A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an asymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.

A pyridazinone derivative represented by the following general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, either one of R.sub.2, R.sub.3 and R.sub.4 represents a hydrogen atom and the remaining two of them represent a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and a salt thereof. The compounds are useful as antihypertensive agents.

Antihypertensive pyridazinone aminoisopropanol derivatives

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Kawasaki, Japan

Kotaro Gotanda