Tanabe Seiyaku Company, Limited

Mitsubishi Tanabe Pharma Corporation

Prosidion Limited

Kosuke Yasuda

Kenji Arakawa

Hiroshi Miyazaki

Takeshi Matsumoto

Masataka Hikota

Hiroshi Morimoto

Iwao Takamuro

Tetsuya Yanagida

Saburo Kawanami

Osamu Sakurai

Yutaka Hisada

Martin James Procter

Matthew Colin Thor Fyfe

Chrystelle Marie Rasamison

Lisa Sarah Gardner

Junko Tsubakimoto

Maseo Nawano

Koichiro Yamada

Karen Lesley Schofield

Vilasben Kanji Shah

Kohei Kikkawa

Rikako Kohno

Junko Okabe

David James Witter

Arlindo Lucas Castelhano

Geoffrey Martyn Williams

Osamu Sakural

Yataka Hisada

An arylalkylamine compound is represented by the following formula [I-e] or a pharmaceutically acceptable salt thereof. 

Arylalkylamine compound and process for preparing the same

The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the above-mentioned compound as an activating compound (CaSR agonist) of a Ca sensing receptor, a pharmaceutical composition containing the above-mentioned compound as an effective ingredient, etc.  The symbols in the formula represent the following meanings:

The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the above-mentioned compound as an activating compound (CaSR agonist) of a Ca sensing receptor, a pharmaceutical composition containing the above-mentioned compound as an effective ingredient, etc. 

The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: 

Nitrogen-containing 5-membered ring compound

Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.

Tri(cyclo) substituted amide compounds

The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings;

Compounds of Formula (I): or pharmaceutically acceptable salts or N-oxides thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.

Tri(cyclo) substituted amide glucokinase activator compounds

Aliphatic nitrogen-containing 5-membered ring compound

Nitrogenous 5-membered ring compounds

The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]:wherein

Aliphatic nitrogenous five-membered ring compounds

Novel sulfonamide derivatives of the formula �I!: ##STR1## wherein Ring A and Ring B are substituted or unsubstituted monocyclic, bicyclic or tricyclic hydrocarbon, or substituted or unsubstituted heterocyclic group, Q is single bond, --O--, --S--, --SO--, --SO.sub.2 -- or --CH.sub.2 --, Y is --0--, --S-- or --NH--, Alk is lower alkylene or alkenylene, Z is --O-- or --NH --, R is substituted or unsubstituted aromatic heterocyclic or aryl, R.sup.1 is H, substituted or unsubstituted amino, substituted or unsubstituted lower alkyl, alkenyl, alkynyl, substituted or unsubstituted lower alkylthio, or alkoxy, or substituted or unsubstituted heterocyclic or aryl, or pharmaceutically acceptable salts thereof, which are useful in the prophylaxis or treatment of disorders associated with endothelin activities such as hypertension, pulmonary hypertension, renal hypertension, Raynaud disease, bronchial asthma, gastric ulcer, chronic heart failure, etc.

Sulfonamide derivative and process for preparing the same

A benzenesulfonamide derivative of the formula �I!: ##STR1## wherein Ring A and Ring B are the same or different and each substituted or unsubstituted benzene ring, Q is a single bond or a group of the formula: --O--, --S--, --SO--, --SO.sub.2 -- or --CH.sub.2 --, Y is a group of the formula: --O--, --S-- or --NH--, Alk is lower alkylene group or lower alkenylene group, Z is a single bond or a group of the formula: --O-- or --NH--, R is a substituted or unsubstituted aromatic heterocyclic or aryl group, R.sup.1 is hydrogen atom, trifluoromethyl group, substituted or unsubstituted lower alkyl group, substituted or unsubstituted lower alkenyl group, mono- or di-lower alkylamino group, substituted or unsubstituted lower alkylthio group, substituted or unsubstituted lower alkoxy group, substituted or unsubstituted lower alkynyl group, aromatic heterocyclic group, substituted or unsubstituted aliphatic heterocyclic group or aryl group, provided that when Z is a single bond, R is a substituted or unsubstituted aromatic heterocyclic group, or a pharmaceutically acceptable salt thereof, and processes for preparing the same, these compounds having endothelin antagonistic activity and being useful in the prophylaxis or treatment of various diseases caused by endothelin.

Benzenesulfonamide derivative and process for preparing thereof

Growing community of inventors

Saitama, Japan

Kosuke Yasuda