Kabushiki Kaisha Toshiba

The Johns Hopkins University

Toshiba Medical Systems Corporation

Kosuke Sakaue

Todd R McNutt

Minoru Nakatsugawa

Robert Davey

Harry Quon

Scott Patrick Robertson

Rachel-Louise Kvertus Koktava

John Wayne Haller

Zhi Cheng

An apparatus for determining a contour of a treatment region in a patient includes a computer processor to receive input regarding a contour of at least one organ-at-risk (OAR) adjacent to the treatment region; receive input regarding an initial contour of the treatment region; predict a radiation toxicity to the at least one OAR based on the contour of the at least one OAR, the initial contour of the treatment region, and a radiation treatment regimen; determine whether the predicted radiation toxicity exceeds a threshold; and determine a contour of the treatment region by iteratively modifying the initial contour of the treatment region, and any subsequent modified contours of the treatment region, until a stopping condition is satisfied. The stopping condition can be a preselected number of iterations or that the predicted radiation toxicity using the contour in place of the initial contour is first calculated is below said threshold.

Method and apparatus for determining treatment region and mitigating radiation toxicity

Growing community of inventors

Otawara, Japan

Kosuke Sakaue