Kissei Pharmaceutical Co., Ltd.

Kosuke Okazaki

Hiroaki Kobayashi

Kenji Yokoyama

Hideki Takeuchi

Makio Kitazawa

Yuichiro Kai

Yoshihiro Terao

Masahiko Uchida

Ken Kikuchi

Norihiko Kikuchi

Tetsuro Tamai

Nobuyuki Tanaka

Harunobu Mukaiyama

Hideyuki Muranaka

Hiroaki Shiohara

Masaru Saito

Yuji Hoyano

Masaaki Ban

Ritsu Suzuki

Ryoichi Yamagishi

Toshikazu Yazaki

Motoyasu Ozawa

The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: 

5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation

The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein Ris a hydrogen atom or an optionally substituted lower alkyl group;

The present invention relates to a 5-amidino-N-(2-aminophenethyl)-2-hydroxybenzenesulfonamide derivative represented by the general formula:wherein Ris a hydrogen atom or a lower alkyl group;

5-amidino-n-(2-aminophenethyl)-n-hydroxy-benzenesulffonamide derivative, medical composition containing the same, pharmaceutical use thereof and intermediate therefor

3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives

3,4-disubstituted phenylethanolaminotetralincarboxamide derivatives

Phenylethanolaminotetralincarboxamide derivatives

Indoline compounds represented by the formula: ##STR1## wherein R represents a saturated or unsaturated aliphatic acyl group which may have one or more halogen atoms, a hydroxy group, a lower alkoxy group, a carboxy group, a lower alkoxycarbonyl group, a cycloalkyl group or an aryl group as substituents; a hydroxyalkyl group; an aliphatic acyloxyalkyl group; a lower alkyl group having a lower alkoxy group, a carboxy group, a lower alkoxycarbonyl group, an aryl substituted lower alkoxycarbonyl group, a carbamoyl group, a mono- or dialkyl substituted carbamoyl group or a cyano group as substituents; an aromatic acyl group which may have one or more halogen atoms as substituents; a furoyl group or a pyridylcarbonyl group; R.sup.1 represents a lower alkyl group which may have one or more halogen atoms or an aryl group as substituents; and pharmaceutically acceptable salts thereof, exhibit a selective suppressive action on urethral contractions, and thus are useful as therapeutic agents for the treatment of dysuria with less hypotension including postural hypotension.

1,5,7-trisubstituted indoline compounds and salts thereof

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Nagano, Japan

Kosuke Okazaki