Nec Corporation

Tokyo Medical University

Other

Japan Science and Technology Agency

Accural Inc.

Mbc, Inc.

Mizutani, Takayuki

Kosuke Oikawa

Masahiko Kuroda

Masakatsu Takanashi

Yoshinori Kosugi

Masami Tanaka

Akihiko Tsuchida

Takayuki Mizutani

Seiko Iizuka

Kazuma Ohyashiki

Tetsuya Ohbayashi

The present invention provides a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject, and an evaluation method using the same. A cancer marker containing at least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as a marker for cancers excluding breast cancer. A method for evaluating the possibility of cancers excluding breast cancer includes the step of detecting the expression level of a cancer marker in a biological sample collected from a subject. In this method, the cancer marker contains at least one miRNA selected from hsa-miR-92 and hsa-miR-494.

Cancer marker, method for evaluation of cancer by using the cancer marker, and evaluation reagent

Disclosed is an identification marker which can be utilized for detection of various human cancer cells and whose expression closely relates to malignant alteration of cells, and compositions for human cancer treatment which are based on suppression of cancer cell proliferation through inhibition of expression of the identification marker. The marker is human heterochromatin protein 1&#x3b3; (HP1&#x3b3;), and the compositions for cancer treatment comprises one or more agents which suppresses the expression of human HP1&#x3b3; gene, such as siRNAs to human HP1&#x3b3;.

Cancer cell identification marker and cancer cell proliferation inhibitor

The expression level of a histamine-releasing factor (HRF) polynucleotide in a biological sample of a subject is measured and the HRF polynucleotide content is compared with that of a normal biological sample. An HRF polynucleotide expression level considerably higher than that of the normal biological sample is employed as an indication of a disease relating to endometriosis or a risk thereof.

Method of diagnosing disease relating to endometriosis

Growing community of inventors

Kunitachi, Japan

Kosuke Oikawa