Yoshitomi Pharmaceutical Industries, Ltd.

Japan Tobacco Inc.

Koretake Anami

Itsuo Uchida

Kunio Iwata

Koji Kobayashi

Akira Saito

Takeshi Kawakita

Junichi Haruta

Tsuguo Ikebe

Mutsuyoshi Matsushita

Noboru Furukawa

Katsuyoshi Hara

Shu Murakami

Chiaki Tashiro

Ichiro Hakamada

Shin Hara

Ichiro Horii

Akihiro Yasuda

Kazuhiko Nishii

Hiroaki Hari

Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof. Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.

Histidyl peptide derivatives

Amino acid derivatives possessing prolyl endopeptidase-inhibitory

Benzolactam compounds of the general formula ##STR1## or isomers thereof as well as salts thereof inclusive of hydrates and/or solvates forms thereof, and benzolactam compounds of the general formula ##STR2## wherein each of the symbols is as defined in the specification. The compound (I) exhibit antiamnesic activity, and are useful as brain function-improving drugs. The compounds (a) and (b) are useful as an intermediate for said compounds (I). Futher, the compound (a) show diuretic or antiulcer activity, and are useful as a diuretic or antiulcer agent.

Benzolactam compounds and pharmaceutical uses thereof

A hydrouracil compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein A represents --CH.dbd.CH--CH.sub.2 -- or --CH.sub.2 CH.sub.2 --, and R represents hydrogen or methyl. Such compounds are useful as analgesics.

Hydrouracil compounds

Growing community of inventors

Nakatsu, Japan

Koretake Anami