Thermo Fisher Scientific Geneart Gmbh

Life Technologies Corporation

Life Technologies As

Korbinian Heil

Geir Fonnum

Kristian Andersson

Robert Jason Potter

Xiquan Liang

Frank Notka

Thomas Poehmerer

Axel Trefzer

Federico Katzen

Namritha Ravinder

Phillip Kuhn

Andreas Zeidler

Yizhu Guo

Sanjay Kumar

Ansgar Romig

This invention relates to polymer particles for solid phase oligonucleotide synthesis. The oligonucleotide may be linked to the particle via a linker having an amide-oligoethyleneglycol-amine structure. The particles may be considered to act as a solid support during the oligonucleotide synthesis. Also disclosed are processes for preparing such polymer particles, compositions and systems comprising such particles, and uses thereof.

Solid support

The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).

High efficiency, small volume nucleic acid synthesis

The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.

CRISPR oligonucleotides and gene editing

Growing community of inventors

Munich, Germany

Korbinian Heil