Centocor, Inc.

The General Hospital Corporation

Centocor Cardiovascular Imaging Partners, L.p.

Koon Y Pak

Richard T Dean

Jeffrey A Mattis

Peter E Daddona

H William Strauss

Ban A Khaw

Harvey J Berger

John Lister-James

Mark Nedelman

Scott Buttram

A one vial method for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is disclosed. The method comprises contacting an antibody mixture comprised of a sulfhydryl containing antibody or antibody fragment and a reducing agent with technetium-99m in an oxidized state. In a preferred embodiment, the antibody mixture further contains a water soluble ligand. A one vial kit for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is also disclosed.

One vial method for labeling antibodies with Technetium-99m

Methods for rapidly labeling sulfhydryl-containing antibodies or fragments with technetium or rhenium radioisotopes are disclosed. The method generally involves combining an aqueous mixture of the radiometal in an oxidized form, a reducing agent and a water-soluble polyhydroxycarbonylic acid ligand to form a stable complex of the radiometal in its reduced state and contacting the mixture with the sulfhydryl-containing antibody or fragment to produce a radiometal-labeled antibody or fragment.

Method for labeling antibodies with a metal ion

A simple, rapid and efficient method for labelling sulfhydryl-containing antibodies or antibody fragments with Tc-99m, Rh-186, Rh-188, Rh-189 or Rh-191 is disclosed. Labeled antibodies produced by the method are useful for radio-immunodiagnostic and/or radio-therapeutic purposes.

Method using technetium-99m imaging agents for the study, detection or diagnosis of ischemic, infarcted or diseased tissue. The imaging agents comprise a complex of technetium-99 m and glucarate.

Organ infarct imaging with technetium labelled glucarate

Method using technetium-99m imaging agents for the study, detection or diagnosis of tumors. The imaging agents comprise a complex of technetium-99m and glucarate.

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Norristown, PA, United States of America

Koon Y Pak