Curacle Co., Ltd.

Yonsei University

Koo Hyeon Ahn

Sung Hwan Kim

Young-Guen Kwon

Myung-Hwa Kim

Chul Su Baek

Jung-In Pyo

Jung-Ln Pyo

Haiying Zhang

Songyi Park

Minyoung Noh

Yeomyeong Kim

Chuk Su Baek

The present invention relates to a crystalline form of (E)-methyl 6-((3S,8S,9S,10R,13S,14S,17R)-3-(((5S,6R)-5-acetoxy-6-(acetoxytnethyl)-5,6-dihydro-2H-pyran-2-yl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10.11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-yl)hept-5-enoate and a blood vessel leak blocker comprising the same. The novel crystalline form has high purity, excellent stability, excellent long-term storage and pharmaceutical stability, and can be used as a vascular leakage blocker, so it is very advantageous in producing high-quality drug substances.

Crystalline form of vascular leakage blocker compound

The present invention relates to a preparation method of a novel vascular leakage blocker with a high yield. The preparation method is easy to react and more productive and economical than the conventional method by using an intermediate that can easily remove impurities generated during the reaction. In addition, the preparation method can produce a novel vascular leakage blocker with a high yield by using a new reagent that has not been previously used in the step of generating an isomer, and is very advantageous in producing a high-quality active pharmaceutical ingredient.

Preparation method of vascular leakage blockers with a high yield

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Seoul, South Korea

Koo Hyeon Ahn