Wisconsin Alumni Research Foundation

University of Chicago

University of Leiden

Konstantinos Dimitrios Potamousis

David Charles Schwartz

Juan Jose De Pablo

Kyubong Jo

Kristy Leigh Kounovsky-Shafer

Juan Pablo Hernandez-Ortiz

Theo Odijk

Michael A Newton

Christopher P Churas

Daniel K Forrest

Rodney Runnheim

Shiguo Zhou

Steven J Goldstein

Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.

System and method for en masse patterning of molecule structures

Methods are provided for ascertaining the sequence of a genomic DNA sample by nicking the DNA sample with a restriction nicking enzyme, followed by nick translation with labeled nucleotides, such that the labeled nucleotides can be quantified and compared to a known, reference genome.

Methods of whole genome analysis

Growing community of inventors

Madison, WI, United States of America

Konstantinos Dimitrios Potamousis